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CDK7 pathway
CDK7 is a cyclin-dependent kinase shown to be not easily classified. CDK7 is both a CDK-activating kinase (CAK) and a component of the general transcription factor TFIIH.
==Introduction==
An intricate network of cyclin-dependent kinases (CDKs) are organized in a pathway to ensure that each cell accurately replicates its DNA and segregate it equally between the two daughter cells.〔Morgan DO. (2007). The Cell Cycle: Principles of Control. New Science Press Ltd: London, UK〕 One CDK–the CDK7 complex–cannot be so easily classified. CDK7 is both a CDK-activating kinase (CAK), which phosphorylates cell-cycle CDKs within the activation segment (T-loop), and a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of the largest subunit of Pol II.〔Harper, J. W., Elledge, S. J., Keyomarski, K., Dynlacht, B., Tsai, L.-H., Zhang, P., Dobrowolski, S., Bai, C., Connell-Crowley, L., Swindell, E. et al. (1995). Inhibition of cyclin-dependent kinases by p21. Mol. Biol. Cell 6, 387-400〕 A proposed mode of CDK7 inhibition is the phosphorylation of cyclin H by CDK7 itself〔Lolli, G., Lowe, E. D., Brown, N. R. and Johnson, L. N. (2004). The crystal structure of human CDK7 and its protein recognition properties. Structure 12, 2067-2079〕 or by another kinase.〔Akoulitchev, S. and Reinberg, D. (1998). The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7. Genes Dev. 12, 3541-3550〕
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